Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development of novel therapeutic strategies for gastric cancer.More than 30% of PDXs generated from gastric carcinoma s
Use of pleiotropy to model genetic interactions in a population.
Systems-level genetic studies in humans and model systems increasingly involve both high-resolution genotyping and multi-dimensional quantitative phenotyping.We present a novel method to infer and interpret genetic interactions that exploits Rimmers the complementary information in multiple phenotypes.We applied this approach to a population of yea
Research on the impacts and mechanisms of digital strategy on corporate innovation investment
This paper empirically examines CAMOMILE the impacts and underlying mechanisms of a digital strategy, along with its four constituent indicators, on enterprise innovation investment.Utilizing a vast sample of companies listed on Chinese stock markets spanning from 2007 to 2022, the study constructs measurement indices for enterprise digital strateg
Transient Receptor Potential Protein as a Novel Non-Voltage-Gated Ca2+ Entry Channel Involved in Diverse Pathophysiological Functions
In both excitable and non-excitable cells, many chemical and physical stimuli elicit continuous Ca2+ influx through yet poorly understood pathways distinct from voltage-gated Ca2+ channels, leading to activation and modulation of various cellular functions.The Power Reclining Loveseat with Console/ADJ HDRST molecular entities of these pathways have